Invasive squamous cell carcinoma of the hand in a patient with Kindler syndrome: Case report and literature review.

[kindler syndrome]

Kindler syndrome is a rare , autosomal , recessive genodermatosis characterized by trauma-induced acral blisters in infancy and childhood , photosensitivity and progressive poikiloderma . Very few cases in the literature report an association with squamous cell carcinoma , even though it is a very well-known , long -term complication . A case involving a 23 -year -old woman with a history of Kindler syndrome who was admitted to the department of plastic surgery (Sherbrooke University , Sherbrooke , Quebec ) with an extensive ulcerated squamous cell carcinoma of the right hand is presented . A local excision of the tumour was initially performed , but positive margins and clinically palpable axillary lymphadenopathy over the course of hospitalization necessitated below-elbow amputation and lymph node dissection . To the authors ' knowledge , this is the second reported case of aggressive metastatic squamous cell carcinoma of the hand in a patient with Kindler syndrome .