Extracellular matrix protein anosmin promotes neural crest formation and regulates FGF, BMP, and WNT activities.

[kallmann syndrome]

Neural crest cells are a transient stem cell-like population appearing during vertebrate embryonic development . Generation of the cranial neural crest is known to require a balanced combination of FGF and BMP levels . However , it is poorly understood how the functions of such growth factors are controlled in the extracellular space . Anosmin is an extracellular matrix protein implicated in FGF signaling and mutated in Kallmann syndrome . Here , we demonstrate that anosmin is synthesized locally in the cranial neural crest of chicken embryos and is essential for cranial neural crest formation . Anosmin upregulates FGF 8 and BMP 5 gene expression ; it also enhances FGF 8 activity while inhibiting BMP 5 and WNT 3 a signaling . Taken together , our data establish that the matrix protein anosmin is required for cranial neural crest formation , with functional modulation of FGF , BMP , and WNT .

Diseases
Validation

Diseases presenting "growth factors" symptom

achondroplasia

alexander disease

aromatase deficiency

cholangiocarcinoma

dentin dysplasia

dentinogenesis imperfecta

dystrophic epidermolysis bullosa

kallmann syndrome

oligodontia

oral submucous fibrosis

primary effusion lymphoma

scrub typhus

severe combined immunodeficiency

You can validate or delete this automatically detected symptom