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What is relationship between the medial preoptic area, the organum vasculosum of the lamina terminalis and Kallmann syndrome?
[kallmann syndrome]
The
medial
preoptic
area
is
a
structure
located
in
the
hypothalamic
anteroventral
third
ventricle
region
,
and
is
closely
related
to
the
olfactory
brain
development
and
sexual
differentiation
of
the
brain
.
The
medial
preoptic
area
surrounds
the
organum
vasculosum
of
the
lamina
terminalis
,
and
both
structures
are
the
main
areas
where
synthesis
of
gonadotropin-releasing
hormone
occurs
in
the
brain
.
Neurons
synthesizing
gonadotropin-releasing
hormone
migrate
from
the
medial
nasal
epithelium
to
the
rostral
brain
and
reach
the
organum
vasculosum
of
the
lamina
terminalis
and
the
medial
preoptic
area
.
Kallmann
syndrome
is
a
genetic
disorder
which
combines
hypogonadotropic
hypogonadism
and
anosmia
.
Hypogonadism
is
characterized
by
the
absence
or
reduced
levels
of
gonadotropin-releasing
hormone
and
anosmia
due
to
olfactory
bulb
aplasia
.
This
paper
speculates
on
the
connection
between
the
development
of
the
medial
preoptic
area
,
the
organum
vasculosum
of
the
lamina
terminalis
and
olfactory
bulbs
with
Kallmann
syndrome
,
since
the
anteroventral
third
ventricle
region
is
crucial
for
the
normal
development
of
these
structures
and
its
connection
with
the
olfactory
nerves
and
sexual
maturation
.
