Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Clinical diagnosis and treatment of male Kallmann syndrome].
[kallmann syndrome]
To
investigate
the
diagnosis
and
treatment
of
male
Kallmann
syndrome
.
We
retrospectively
analyzed
the
clinical
data
of
12
cases
of
male
Kallmann
syndrome
,
3
treated
for
male
sterility
and
the
other
9
for
secondary
sex
characteristics
dysplasia
and
external
genitalia
developmental
anomalies
,
all
by
combined
replacement
therapy
with
human
chorionic
gonadotropin
(
hCG
)
,
human
menopause
gonadotropin
(
hMG
)
and
testosterone
undecanoate
for
6
months
to
3
years
.
We
compared
the
secondary
sexual
development
and
serum
sex
hormone
levels
of
the
patients
before
and
after
treatment
.
After
9
months
of
treatment
,
all
the
12
patients
showed
significant
improvement
in
the
penile
length
,
testicular
volume
and
sex
hormone
levels
(
P
<
0
.
01
)
,
with
different
degrees
of
promotion
of
the
secondary
sexual
development
.
Three
married
cases
could
have
normal
sexual
intercourse
,
and
one
of
them
achieved
normal
pregnancy
.
The
clinical
characteristics
of
Kallmann
syndrome
include
lack
of
gonadotropins
,
lower
gonad
function
and
loss
or
reduction
of
olfactory
sensation
.
Replacement
therapy
with
hCG
,
hMG
and
androgens
is
an
effective
treatment
method
.
However
,
no
effective
therapy
is
now
available
for
olfactory
dysfunction
.
Early
diagnosis
and
hormone
replacement
therapy
can
best
alleviate
its
clinical
symptoms
and
eventually
achieve
fertility
.
Diseases
Validation
Diseases presenting
"lower gonad function and loss or reduction of olfactory sensation"
symptom
kallmann syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom