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Our Team
[Clinical diagnosis and treatment of male Kallmann syndrome].
[kallmann syndrome]
To
investigate
the
diagnosis
and
treatment
of
male
Kallmann
syndrome
.
We
retrospectively
analyzed
the
clinical
data
of
12
cases
of
male
Kallmann
syndrome
,
3
treated
for
male
sterility
and
the
other
9
for
secondary
sex
characteristics
dysplasia
and
external
genitalia
developmental
anomalies
,
all
by
combined
replacement
therapy
with
human
chorionic
gonadotropin
(
hCG
)
,
human
menopause
gonadotropin
(
hMG
)
and
testosterone
undecanoate
for
6
months
to
3
years
.
We
compared
the
secondary
sexual
development
and
serum
sex
hormone
levels
of
the
patients
before
and
after
treatment
.
After
9
months
of
treatment
,
all
the
12
patients
showed
significant
improvement
in
the
penile
length
,
testicular
volume
and
sex
hormone
levels
(
P
<
0
.
01
)
,
with
different
degrees
of
promotion
of
the
secondary
sexual
development
.
Three
married
cases
could
have
normal
sexual
intercourse
,
and
one
of
them
achieved
normal
pregnancy
.
The
clinical
characteristics
of
Kallmann
syndrome
include
lack
of
gonadotropins
,
lower
gonad
function
and
loss
or
reduction
of
olfactory
sensation
.
Replacement
therapy
with
hCG
,
hMG
and
androgens
is
an
effective
treatment
method
.
However
,
no
effective
therapy
is
now
available
for
olfactory
dysfunction
.
Early
diagnosis
and
hormone
replacement
therapy
can
best
alleviate
its
clinical
symptoms
and
eventually
achieve
fertility
.
Diseases
Validation
Diseases presenting
"external genitalia developmental anomalies"
symptom
kallmann syndrome
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