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The hypothetical role of congenital hypotonia in the development of early coronoid hyperplasia.
[kabuki syndrome]
Coronoid
hyperplasia
(
CH
)
is
an
abnormal
bony
elongation
of
a
histologically
normal
coronoid
process
.
Its
definitive
cause
remains
unknown
.
To
analyze
the
possible
implication
of
congenital
hypotonia
in
the
pathogenesis
of
early
coronoid
overgrowth
.
Two
infants
with
congenital
hypotonia
were
evaluated
for
limited
mouth
aperture
.
Bilateral
CH
was
diagnosed
.
Transoral
coronoidectomy
was
followed
by
an
early
dynamic
physiotherapy
program
.
Significant
improvement
of
maximum
interincisal
opening
was
achieved
.
The
review
of
the
scientific
literature
proved
the
diagnosis
of
CH
in
the
infant
age
group
is
extremely
unusual
and
the
etiology
of
the
condition
is
still
uncertain
.
Besides
mouth
opening
restriction
,
clinical
features
of
coronoid
hyperplasia
in
infants
can
include
suction
or
deglutition
anomalies
,
failure
to
thrive
and
recurrent
episodes
of
choking
or
aspiration
pneumonia
.
The
authors
hypothesize
reduced
fetal
mandibular
movements
and
deglutition
as
a
result
of
congenital
hypotonia
may
lead
to
relative
hyperactivity
of
the
temporalis
muscle
that
is
not
counterbalanced
by
the
infra
and
suprahyoid
muscles
,
thereby
facilitating
coronoid
overgrowth
.
Diseases
Validation
Diseases presenting
"failure to thrive"
symptom
22q11.2 deletion syndrome
alexander disease
child syndrome
congenital diaphragmatic hernia
cystinuria
familial hypocalciuric hypercalcemia
hirschsprung disease
homocystinuria without methylmalonic aciduria
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
krabbe disease
neonatal adrenoleukodystrophy
omenn syndrome
papillon-lefèvre syndrome
pyruvate dehydrogenase deficiency
triple a syndrome
wolf-hirschhorn syndrome
zellweger syndrome
This symptom has already been validated