Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Two dogs with juvenile-onset skin diseases with involvement of extremities.
[junctional epidermolysis bullosa]
Two
dogs
of
juvenile
-onset
skin
diseases
with
involvement
of
extremities
were
examined
by
histopathological
,
immunohistochemical
and
ultrastructural
analyses
.
Clinically
,
both
cases
showed
alopecia
and
crusts
on
the
face
and
extremities
.
Case
1
showed
histopathology
of
dermo-epidermal
separation
.
Ultrastructural
analysis
revealed
that
the
clefts
were
recognized
between
hemidesmosomes
and
lamina
densa
.
In
case
2
,
histopathology
showed
follicular
atrophy
,
vacuolar
degeneration
at
lower
epidermis
and
masseter
muscle
degeneration
,
without
remarkable
ultrastructural
abnormalities
in
basement
membrane
zone
of
the
skin
.
Thus
,
the
findings
in
case
1
were
compatible
to
those
in
junctional
epidermolysis
bullosa
,
while
those
in
case
2
were
compatible
to
dermatomyositis
-like
disease
.
Combination
of
histopathological
and
ultrastructural
analyses
was
useful
to
distinguish
the
diseases
in
two
dogs
.
Diseases
Validation
Diseases presenting
"alopecia"
symptom
cadasil
congenital adrenal hyperplasia
cutaneous mastocytosis
epidermolysis bullosa simplex
harlequin ichthyosis
junctional epidermolysis bullosa
lamellar ichthyosis
oligodontia
omenn syndrome
pleomorphic liposarcoma
proteus syndrome
werner syndrome
This symptom has already been validated