Rare Diseases Symptoms Automatic Extraction
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Two dogs with juvenile-onset skin diseases with involvement of extremities.
[junctional epidermolysis bullosa]
Two
dogs
of
juvenile
-onset
skin
diseases
with
involvement
of
extremities
were
examined
by
histopathological
,
immunohistochemical
and
ultrastructural
analyses
.
Clinically
,
both
cases
showed
alopecia
and
crusts
on
the
face
and
extremities
.
Case
1
showed
histopathology
of
dermo-epidermal
separation
.
Ultrastructural
analysis
revealed
that
the
clefts
were
recognized
between
hemidesmosomes
and
lamina
densa
.
In
case
2
,
histopathology
showed
follicular
atrophy
,
vacuolar
degeneration
at
lower
epidermis
and
masseter
muscle
degeneration
,
without
remarkable
ultrastructural
abnormalities
in
basement
membrane
zone
of
the
skin
.
Thus
,
the
findings
in
case
1
were
compatible
to
those
in
junctional
epidermolysis
bullosa
,
while
those
in
case
2
were
compatible
to
dermatomyositis
-like
disease
.
Combination
of
histopathological
and
ultrastructural
analyses
was
useful
to
distinguish
the
diseases
in
two
dogs
.