Inherited junctional epidermolysis bullosa (Herlitz type) in German black-headed mutton sheep.

[junctional epidermolysis bullosa]

This report describes the microscopical , immunohistochemical and ultrastructural findings in the first ovine cases of the Herlitz type of inherited junctional epidermolysis bullosa . Sixteen German black-headed mutton lambs and one crossbred lamb had blisters and ulceration of the skin and mucous membranes in addition to alterations of the horn of the hooves . Microscopically , there was separation of the dermoepidermal junction , which was confirmed to be located in the lamina lucida of the basement membrane by electron microscopy . In areas of subepidermal splitting the hemidesmosomes were missing and in adjacent areas they appeared to be rudimentary and reduced in number . Immunohistochemistry for laminin 5 revealed a markedly reduced expression of this molecule on the dermal side of the blisters , while expression of collagen VII was normal .

Diseases
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Diseases presenting "one crossbred lamb had blisters and ulceration of the skin and mucous membranes in addition to alterations of the horn of the hooves" symptom

junctional epidermolysis bullosa

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