Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
22q11.2 Deletion syndrome is associated with increased perioperative events and more complicated postoperative course in infants undergoing infant operative correction of truncus arteriosus communis or interrupted aortic arch.
[22q11.2 deletion syndrome]
The
effect
of
genotype
on
the
outcomes
of
infant
cardiac
operations
has
not
been
well
established
.
The
purpose
of
the
present
study
was
to
investigate
the
effect
of
22
q
11
.
2
deletion
(
22
q
11
del
)
on
infants
with
truncus
arteriosus
communis
(
TA
)
and
interrupted
aortic
arch
(
IAA
)
undergoing
operative
correction
during
infancy
.
We
conducted
a
retrospective
cohort
study
of
all
infants
who
had
undergone
operative
correction
of
TA
or
IAA
at
the
Children
's
Hospital
of
Philadelphia
from
1995
to
2007
,
comparing
the
perioperative
outcomes
(
hospital
length
of
stay
,
intensive
care
,
mechanical
ventilation
,
risk
of
cardiac
and
noncardiac
events
,
number
of
consultations
,
and
number
of
discharge
medications
)
by
22
q
11
del
status
.
A
total
of
104
patients
were
studied
(
55
with
TA
and
49
with
IAA
)
,
of
whom
40
(
38
%
)
were
22
q
11
del
positive
.
The
22
q
11
del
status
was
unknown
in
9
(
7
with
TA
and
2
with
IAA
)
.
In
patients
with
known
deletion
status
,
those
with
22
q
11
del
had
a
longer
hospital
and
intensive
care
length
of
stay
.
Subjects
with
22
q
11
del
also
required
more
frequent
operative
reintervention
and
more
consultations
and
were
prescribed
more
medications
at
discharge
.
No
significant
difference
was
found
in
method
of
feeding
between
those
with
and
without
22
q
11
del
at
discharge
.
In
this
study
,
22
q
11
del
is
associated
with
perioperative
outcomes
in
infants
undergoing
operative
correction
of
TA
and
IAA
,
with
longer
hospital
stays
and
greater
resource
utilization
in
the
perioperative
period
.
These
findings
should
inform
counseling
and
risk
stratification
and
warrant
additional
study
to
identify
genotype-
specific
management
strategies
to
improve
outcomes
.
Diseases
Validation
Diseases presenting
"truncus arteriosus"
symptom
22q11.2 deletion syndrome
holt-oram syndrome
This symptom has already been validated
