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The potential role of small heat shock proteins in mitochondria.
[inclusion body myositis]
Mitochondria
play
a
central
role
in
cellular
metabolism
,
calcium
homeostasis
,
redox
signaling
and
cell
fates
.
Mitochondrial
homeostasis
is
tightly
regulated
,
and
mitochondrial
dysfunction
is
frequently
associated
with
severe
human
pathologies
.
Small
heat
shock
proteins
are
molecular
chaperones
that
play
major
roles
in
development
,
stress
responses
,
and
diseases
,
and
have
been
envisioned
as
targets
for
therapy
.
The
mechanisms
that
lie
behind
the
cytoprotection
of
small
heat
shock
proteins
are
related
to
the
regulation
of
mitochondrial
functions
.
This
review
recapitulates
the
current
knowledge
of
the
expression
of
various
small
heat
shock
proteins
in
mitochondria
and
discusses
their
implication
in
the
role
of
mitochondria
and
their
regulation
.
Based
on
their
involvement
in
mitochondrial
normal
physiology
and
pathology
,
a
better
understanding
of
their
roles
and
regulation
will
pave
the
way
for
innovative
approaches
for
the
successful
treatment
of
a
range
of
stress-related
syndromes
whose
etiology
is
based
upon
dysfunction
of
mitochondria
.
Diseases
Validation
Diseases presenting
"small heat shock proteins"
symptom
alexander disease
hereditary cerebral hemorrhage with amyloidosis
inclusion body myositis
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