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Incidence and prevalence of idiopathic inflammatory myopathies in South Australia: a 30-year epidemiologic study of histology-proven cases.
[inclusion body myositis]
To
describe
the
epidemiology
of
biopsy-proven
idiopathic
inflammatory
myopathies
(
IIM
)
in
South
Australia
(
SA
)
.
Cases
of
IIM
were
ascertained
by
review
of
all
muscle
biopsy
reports
from
the
Neuropathology
Laboratory
,
Hanson
Institute
(
wherein
all
adult
muscle
biopsies
in
SA
are
reported
)
from
1980
to
2009
.
Clinical
correlation
of
these
patients
by
review
of
medical
records
was
undertaken
.
SA
population
denominator
numbers
were
obtained
from
the
Australian
Bureau
of
Statistics
.
T
hree
hundred
and
fifty-
two
biopsy-proven
cases
of
IIM
were
identified
between
1980
and
2009
.
The
overall
annual
incidence
of
IIM
appeared
to
be
rising
with
a
mean
incidence
of
eight
cases
per
million
population
(
95
%
CI
:
7
.
2
-
8
.
9
)
.
This
corresponded
with
an
increasing
annual
incidence
of
inclusion
body
myositis
(
IBM
)
(
prevalence
of
50
.
5
cases
per
million
population
in
2009
,
95
%
CI
:
40
.
2
-
62
.
7
)
.
A
female
preponderance
was
noted
in
both
dermatomyositis
(
DM
)
(
F
:
M
=
2
.
75
:
1
.
00
)
and
polymyositis
(
PM
)
(
F
:
M
=
1
.
55
:
1
.
00
)
but
gender
distribution
was
almost
equal
in
IBM
(
F
:
M
=
1
.
1
:
1
.
0
)
.
Mean
age
at
diagnosis
for
IBM
(
67
.
5
years
)
was
higher
than
for
DM
(
55
.
1
years
)
and
PM
(
59
.
0
years
)
.
A
higher
proportion
of
DM
patients
reported
living
in
urban
dwellings
and
DM
patients
tended
to
be
predominantly
professionals
.
In
SA
there
is
an
increasing
incidence
of
IBM
and
the
prevalence
is
one
of
the
highest
reported
to
date
.
This
may
reflect
an
increase
in
the
number
of
biopsies
performed
,
improved
histological
techniques
or
a
genuine
increase
in
incidence
.
