Biomarkers of inclusion body myositis.

[inclusion body myositis]

Inclusion body myositis (IBM ) is a poorly understood autoimmune and degenerative disorder of skeletal muscle . Here , pathophysiological and diagnostic biomarkers of IBM are reviewed .Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiology for over three decades . Their use as diagnostic biomarkers , in contrast , has significant limitations . A blood biomarker , autoantibodies against a 43 -kDa muscle protein reported in 2011 , has now been identified as targeting cytoplasmic 5 ' nucleotidase (cN 1 A ; NT 5 C 1 A ), a protein involved in nucleic acid metabolism . Diagnostic testing for these autoantibodies is of high diagnostic performance for IBM .Muscle biomarkers have suggested that IBM pathophysiology is linked to myonuclear degeneration and disordered nucleic acid metabolism . A blood biomarker has high diagnostic performance for IBM , and through identification of its target links , IBM autoimmunity and degeneration together , supporting the view that IBM pathophysiology includes abnormal nucleic acid metabolism .