[Idiopathic inflammatory myopathies from the viewpoint of a neurologist].

[inclusion body myositis]

Idiopathic inflammatory myopathies (IIMs ) are a heterogeneous group of systemic autoimmune disorders characterized by inflammation of skeletal muscle . In Japan , patients with IIMs usually visit a dermatologist , rheumatologist , or neurologist depending on the main symptom . Because most of the patients with IIMs have muscle weakness as a main symptom , muscle biopsy is usually performed to differentiate these from other non-inflammatory myopathies . Thus , neurologists in Japan tend to consider mostly the pathological findings in the diagnosis and classification of IIMs . From this background , IIMs have been classified into four pathologically distinct subsets : polymyositis , dermatomyositis , necrotizing autoimmune myositis , and sporadic inclusion body myositis . However , in clinical practice , the percentage of patients with typical pathological findings is generally not high . Therefore , other clinical factors , including rash or clinical complications (malignancy , collagen diseases , or interstitial pneumonitis ), have been used along with pathological classification . With the recent discovery of new myositis -specific autoantibodies (MSAs ) by rheumatologists and dermatologists , it has been suggested that the presence of a MSA is another important factor for classification . To develop useful methods of classification and to reveal the pathological mechanisms of IIMs , further collaborative studies by dermatologists , rheumatologists , and neurologists are necessary .

Diseases
Validation

Diseases presenting "inflammatory myopathies" symptom

familial mediterranean fever

focal myositis

inclusion body myositis

pyomyositis

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