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The 2-min walk test is sufficient for evaluating walking abilities in sporadic inclusion body myositis.
[inclusion body myositis]
Sporadic
inclusion
body
myositis
causes
progressive
functional
loss
due
to
declining
muscle
strength
.
Although
the
underlying
cause
is
unknown
,
clinical
trials
are
underway
to
improve
strength
and
function
.
Selection
of
appropriate
outcome
measures
is
critical
for
the
success
of
these
trials
.
The
6
-
min
walk
test
has
been
the
de
facto
standard
for
assessing
function
in
neuromuscular
disease
;
however
,
the
optimal
walking
test
has
not
been
determined
in
this
disease
.
In
this
study
,
67
individuals
with
sporadic
inclusion
body
myositis
completed
a
battery
of
quantitative
strength
and
functional
tests
including
timed
walking
tests
,
patient-reported
outcomes
,
and
other
tasks
.
The
2
-
min
and
6
-
min
walk
tests
are
highly
correlated
to
each
other
(
r
=
0
.
97
,
p
<
0
.
001
)
and
to
all
lower
extremity
strength
,
patient-reported
,
and
functional
measures
in
this
population
.
All
subjects
completed
the
2
-
min
walk
test
,
but
7
%
of
subjects
were
unable
to
walk
the
full
6
-
min
of
the
6
-
min
walk
test
due
to
fatigue
.
The
2
-
min
walk
test
demonstrates
similar
correlation
to
all
outcomes
compared
to
the
6
-
min
walk
test
,
is
less
fatiguing
and
better
tolerated
.
Results
suggest
that
the
2
-
min
walk
test
is
a
better
alternative
to
tests
of
longer
duration
.
Further
research
is
needed
to
determine
longitudinal
changes
on
this
outcome
.
Diseases
Validation
Diseases presenting
"further research"
symptom
22q11.2 deletion syndrome
achondroplasia
canavan disease
child syndrome
esophageal adenocarcinoma
harlequin ichthyosis
heparin-induced thrombocytopenia
inclusion body myositis
junctional epidermolysis bullosa
legionellosis
neuralgic amyotrophy
oculocutaneous albinism
phenylketonuria
waldenström macroglobulinemia
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