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Inclusion body myositis: a case of bilateral extremity weakness.
[inclusion body myositis]
Inflammatory
myopathy
is
a
common
cause
of
bilateral
muscular
weakness
in
adults
.
Although
not
as
common
as
polymyositis
,
inclusion
body
myositis
(
IBM
)
is
a
form
of
inflammatory
myopathy
characterized
by
chronic
progressive
muscle
inflammation
and
often
goes
undiagnosed
and
untreated
.
IBM
patients
most
commonly
present
with
proximal
lower
extremity
weakness
and
may
have
normal
creatine
kinase
(
CK
)
levels
.
A
high
level
of
clinical
suspicion
is
required
for
prompt
and
accurate
diagnosis
of
IBM
,
which
is
diagnosed
definitively
with
a
muscle
biopsy
.
The
patient
described
in
this
case
report
is
a
68
-
year
-old
man
who
initially
presented
with
both
bilateral
symmetric
proximal
lower
extremity
and
distal
upper
extremity
weakness
.
IBM
was
suspected
through
history
,
electromyography
,
and
definitively
diagnosed
with
muscle
biopsy
.
The
patient
was
subsequently
initiated
on
prednisone
therapy
and
physical
therapy
,
with
improvement
in
muscular
strength
after
2
months
.
In
patients
presenting
with
bilateral
extremity
weakness
and
normal
CK
level
,
the
diagnosis
of
IBM
should
be
included
in
the
differential
diagnosis
and
muscle
biopsy
performed
for
appropriate
cases
.
Diseases
Validation
Diseases presenting
"common cause"
symptom
achondroplasia
acute rheumatic fever
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
alpha-thalassemia
aniridia
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
child syndrome
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congenital adrenal hyperplasia
congenital toxoplasmosis
cushing syndrome
erdheim-chester disease
esophageal adenocarcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
lamellar ichthyosis
legionellosis
liposarcoma
locked-in syndrome
malignant atrophic papulosis
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systemic capillary leak syndrome
thoracic outlet syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
zellweger syndrome
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