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Inclusion body myositis: a case of bilateral extremity weakness.
[inclusion body myositis]
Inflammatory
myopathy
is
a
common
cause
of
bilateral
muscular
weakness
in
adults
.
Although
not
as
common
as
polymyositis
,
inclusion
body
myositis
(
IBM
)
is
a
form
of
inflammatory
myopathy
characterized
by
chronic
progressive
muscle
inflammation
and
often
goes
undiagnosed
and
untreated
.
IBM
patients
most
commonly
present
with
proximal
lower
extremity
weakness
and
may
have
normal
creatine
kinase
(
CK
)
levels
.
A
high
level
of
clinical
suspicion
is
required
for
prompt
and
accurate
diagnosis
of
IBM
,
which
is
diagnosed
definitively
with
a
muscle
biopsy
.
The
patient
described
in
this
case
report
is
a
68
-
year
-old
man
who
initially
presented
with
both
bilateral
symmetric
proximal
lower
extremity
and
distal
upper
extremity
weakness
.
IBM
was
suspected
through
history
,
electromyography
,
and
definitively
diagnosed
with
muscle
biopsy
.
The
patient
was
subsequently
initiated
on
prednisone
therapy
and
physical
therapy
,
with
improvement
in
muscular
strength
after
2
months
.
In
patients
presenting
with
bilateral
extremity
weakness
and
normal
CK
level
,
the
diagnosis
of
IBM
should
be
included
in
the
differential
diagnosis
and
muscle
biopsy
performed
for
appropriate
cases
.
Diseases
Validation
Diseases presenting
"weakness"
symptom
achondroplasia
adrenomyeloneuropathy
alexander disease
aniridia
aromatase deficiency
coats disease
congenital toxoplasmosis
epidermolysis bullosa simplex
esophageal adenocarcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
focal myositis
gm1 gangliosidosis
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
pendred syndrome
pleomorphic liposarcoma
pyomyositis
pyruvate dehydrogenase deficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
werner syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated