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Eosinophils in hereditary and inflammatory myopathies.
[inclusion body myositis]
It
is
not
known
whether
eosinophilic
myositis
is
a
specific
histopathological
feature
of
limb
girdle
muscular
dystrophy
2
A
(
LGMD
2
A
)
.
Number
and
location
of
eosinophils
in
skeletal
muscle
biopsies
(
n
=
100
)
was
analysed
by
Giemsa
and
modified
hematoxylin
/
eosin
staining
in
patients
with
genetically
confirmed
myopathies
(
LGMD
2
A
,
LGMD
2
B
,
LGMD
2
L
,
facioscapulohumeral
muscular
dystrophy
,
dystrophinopathy
)
,
histologically
confirmed
idiopathic
inflammatory
myopathies
(
sporadic
inclusion
body
myositis
(
sIBM
)
,
dermatomyositis
(
DM
)
,
polymyositis
)
,
amyotrophic
lateral
sclerosis
(
neurogenic
control
)
,
and
normal
controls
.
The
number
of
eosinophils
/
mm
²
was
significantly
higher
in
LGMD
2
A
,
PM
,
DM
,
and
sIBM
compared
to
controls
but
not
significantly
higher
than
other
myopathies
.
A
large
overlap
in
the
number
of
eosinophils
/
mm
2
between
all
groups
was
seen
.
In
all
disease
groups
eosinophils
were
mainly
found
endomysially
(
46
-
88
%
)
and
intra-
and
perivascularly
(
4
-
37
%
)
.
There
was
no
correlation
between
the
numbers
of
eosinophils
/
mm
²
and
(
i
)
age
at
biopsy
and
(
ii
)
the
duration
of
the
disease
.
The
extent
of
myopathic
,
fibrotic
,
and
inflammatory
changes
did
not
differ
in
samples
with
high
and
low
eosinophil
count
.
Eosinophils
seem
to
represent
an
unspecific
histological
finding
in
hereditary
and
inflammatory
myopathies
,
but
also
amyotrophic
lateral
sclerosis
.
Diseases
Validation
Diseases presenting
"specific histopathological feature"
symptom
inclusion body myositis
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