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Four-year longitudinal study of clinical and functional endpoints in sporadic inclusion body myositis: implications for therapeutic trials.
[inclusion body myositis]
Natural
history
studies
in
sporadic
inclusion
body
myositis
are
of
fundamental
interest
for
future
therapeutic
trials
.
Previous
works
have
demonstrated
the
particular
relevance
of
knee
extension
strength
in
the
follow-up
of
this
disease
.
This
work
aimed
to
extend
a
preceding
natural
history
over
9
months
to
a
four
year
period
.
Thirteen
patients
were
assessed
using
clinical
and
functional
scales
and
dynamometry
.
Except
wrist
extension
torque
and
manual
muscle
testing
composite
score
,
all
the
measurements
presented
a
significant
decline
.
The
most
important
changes
were
observed
for
knee
extension
and
ankle
flexion
and
extension
.
The
relative
change
in
knee
extension
strength
correlated
with
the
level
of
strength
at
baseline
.
A
non-linear
correlation
was
found
between
6
-
minute
walk
distance
and
knee
extension
strength
.
This
study
confirms
that
knee
extension
strength
is
particularly
relevant
to
follow
patients
with
sporadic
inclusion
body
myositis
.
It
also
shows
that
a
strength
loss
does
not
have
linear
consequences
on
motor
ability
.
Finally
strength
and
motor
ability
are
complementing
each
other
in
the
understanding
of
disease
progression
.