Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Blood flow restricted resistance training attenuates myostatin gene expression in a patient with inclusion body myositis.
[inclusion body myositis]
Inclusion
body
myositis
is
a
rare
idiopathic
inflammatory
myopathy
that
produces
extreme
muscle
weakness
.
Blood
flow
restricted
resistance
training
has
been
shown
to
improve
muscle
strength
and
muscle
hypertrophy
in
inclusion
body
myositis
.
The
aim
of
this
study
was
to
evaluate
the
effects
of
a
resistance
training
programme
on
the
expression
of
genes
related
to
myostatin
(
MSTN
)
signalling
in
one
inclusion
body
myositis
patient
.
A
65
-
year
-old
man
with
inclusion
body
myositis
underwent
blood
flow
restricted
resistance
training
for
12
weeks
.
The
gene
expression
of
MSTN
,
follistatin
,
follistatin
-like
3
,
activin
II
B
receptor
,
SMAD-
7
,
MyoD
,
FOXO-
3
,
and
MURF-
2
was
quantified
.
After
12
weeks
of
training
,
a
decrease
(
25
%
)
in
MSTN
mRNA
level
was
observed
,
whereas
follistatin
and
follistatin
-like
3
gene
expression
increased
by
40
%
and
70
%
,
respectively
.
SMAD-
7
mRNA
level
was
augmented
(
20
%
)
.
FOXO-
3
and
MURF-
2
gene
expression
increased
by
40
%
and
20
%
,
respectively
.
No
change
was
observed
in
activin
II
B
receptor
or
MyoD
gene
expression
.
Blood
flow
restricted
resistance
training
attenuated
MSTN
gene
expression
and
also
increased
expression
of
myostatin
endogenous
inhibitors
.
Blood
flow
restricted
resistance
training
evoked
changes
in
the
expression
of
genes
related
to
MSTN
signalling
pathway
that
could
in
part
explain
the
muscle
hypertrophy
previously
observed
in
a
patient
with
inclusion
body
myositis
.
Diseases
Validation
Diseases presenting
"inflammatory myopathy"
symptom
focal myositis
inclusion body myositis
pyomyositis
This symptom has already been validated