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The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications.
[inclusion body myositis]
The
idiopathic
inflammatory
myopathies
are
a
heterogeneous
group
of
autoimmune
muscle
disorders
with
distinct
clinical
and
pathological
features
and
underlying
immunopathogenic
mechanisms
.
Traditionally
,
CD
4
(
+
)
Th
1
cells
or
CD
8
(
+
)
cytotoxic
effector
T
cells
and
type
I
/
II
interferons
have
been
primarily
implicated
in
the
pathogenesis
of
the
inflammatory
myopathies
.
The
presence
of
IL
-
17
A
producing
cells
in
the
inflamed
muscle
tissue
of
myositis
patients
and
the
results
of
in
vitro
studies
suggest
that
IL
-
17
A
and
the
Th
17
pathway
may
also
have
a
key
role
in
these
diseases
.
The
contribution
of
IL
-
17
A
to
other
chronic
inflammatory
and
autoimmune
diseases
has
been
well
established
and
clinical
trials
of
IL
-
17
A
inhibitors
are
now
at
an
advanced
stage
.
However
the
precise
role
of
IL
-
17
A
in
the
various
forms
of
myositis
and
the
potential
for
therapeutic
targeting
is
currently
unknown
and
warrants
further
investigation
.
Diseases
Validation
Diseases presenting
"advanced stage"
symptom
carcinoma of the gallbladder
coats disease
dedifferentiated liposarcoma
erdheim-chester disease
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
inclusion body myositis
liposarcoma
oral submucous fibrosis
wiskott-aldrich syndrome
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