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Incidence and prevalence of inflammatory myopathies: a systematic review.
[inclusion body myositis]
.
The
aims
of
this
study
were
to
determine
the
incidence
and
prevalence
of
inflammatory
myopathies
(
IMs
)
,
their
epidemiological
tendencies
over
time
and
their
possible
key
determinants
.
.
All
original
articles
in
English
or
French
regarding
the
prevalence
and
/
or
incidence
of
IMs
were
searched
.
The
methods
of
case
ascertainment
,
epidemiological
analysis
and
diagnostic
criteria
were
systematically
analysed
.
.
Forty
-
six
articles
published
between
1966
and
2013
were
found
in
which
the
incidence
of
IMs
as
a
whole
ranged
from
1
.
16
to
19
/
million
/
year
and
their
prevalence
ranged
from
2
.
4
to
33
.
8
per
100
000
inhabitants
.
Methodological
heterogeneities
limited
comparisons
,
although
certain
epidemiological
tendencies
were
highlighted
.
The
relative
incidence
of
DM
may
follow
a
latitudinal
gradient
in
the
northern
hemisphere
that
may
be
explained
by
the
immunomodulatory
action
of
ultraviolet
radiation
.
The
prevalence
of
sporadic
inclusion
body
myositis
(
sIBM
)
was
correlated
with
the
frequency
of
HLA-
DR
3
.
Juvenile
myositis
onset
was
non-random
over
seasons
and
/
or
time
,
consistent
with
a
role
of
infectious
diseases
,
although
other
environmental
factors
may
be
involved
.
Disparities
according
to
sex
,
age
and
geographical
origin
were
also
found
.
The
frequency
of
IM
increased
over
time
,
which
may
reflect
progress
in
diagnostic
performance
,
although
there
is
still
a
need
to
increase
the
level
of
awareness
with
regard
to
these
diseases
,
especially
sIBM
,
as
attested
by
its
considerably
delayed
diagnosis
.
.
This
first
systematic
literature
review
confirms
the
rarity
of
IM
and
may
highlight
certain
genetic
and
environmental
determinants
of
IM
.
There
is
a
need
for
uniformity
in
diagnostic
and
classification
criteria
as
well
as
more
exhaustive
case
ascertainment
to
refine
IM
epidemiology
.
Diseases
Validation
Diseases presenting
"juvenile myositis onset"
symptom
inclusion body myositis
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