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Sleep disordered breathing and subclinical impairment of respiratory function are common in sporadic inclusion body myositis.
[inclusion body myositis]
Relatively
little
is
known
about
frequency
and
extent
of
respiratory
problems
in
sporadic
inclusion
body
myositis
(
IBM
)
.
To
address
this
issue
a
study
of
peripheral
muscle
and
respiratory
function
and
related
symptoms
was
performed
in
a
cohort
with
biopsy-proven
IBM
.
Dyspnoea
,
daytime
sleepiness
,
dysphagia
,
spirometry
,
respiratory
muscle
strength
,
arterial
blood
gas
tensions
and
ventilation
during
sleep
were
assessed
.
Sixteen
patients
were
studied
(
10
males
;
age
68
.
1
±
9
.
9
years
;
disease
duration
11
.
9
±
5
.
0
years
;
body
mass
index
28
.
5
±
4
.
0
kg
/
m
(
2
)
)
.
Four
reported
excessive
daytime
sleepiness
;
8
had
at
least
mild
dysphagia
;
forced
vital
capacity
was
<
80
%
predicted
normal
in
7
;
sniff
nasal
inspiratory
pressure
was
reduced
in
3
;
daytime
hypoxemia
was
present
in
9
and
hypercapnia
in
one
.
Sleep
study
was
performed
in
15
and
revealed
sleep
disordered
breathing
(
apnoea
-hypopnoea
index
23
.
4
±
12
.
8
(
range
7
-
50
.
3
)
events
/
h
)
in
all
.
There
were
no
consistent
relationships
between
respiratory
function
impairment
,
occurrence
of
sleep
disordered
breathing
,
and
severity
of
peripheral
muscle
weakness
.
Thus
,
asymptomatic
impairment
of
respiratory
function
was
common
and
sleep
disordered
breathing
observed
in
all
patients
tested
,
irrespective
of
daytime
respiratory
function
.
This
suggests
respiratory
function
testing
,
including
sleep
study
,
should
be
performed
routinely
in
IBM
,
irrespective
of
peripheral
muscle
function
or
other
disease
severity
parameters
.
Diseases
Validation
Diseases presenting
"dysphagia"
symptom
alexander disease
cadasil
cushing syndrome
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
inclusion body myositis
kindler syndrome
liposarcoma
locked-in syndrome
neuralgic amyotrophy
oligodontia
triple a syndrome
well-differentiated liposarcoma
This symptom has already been validated