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Sleep disordered breathing and subclinical impairment of respiratory function are common in sporadic inclusion body myositis.
[inclusion body myositis]
Relatively
little
is
known
about
frequency
and
extent
of
respiratory
problems
in
sporadic
inclusion
body
myositis
(
IBM
)
.
To
address
this
issue
a
study
of
peripheral
muscle
and
respiratory
function
and
related
symptoms
was
performed
in
a
cohort
with
biopsy-proven
IBM
.
Dyspnoea
,
daytime
sleepiness
,
dysphagia
,
spirometry
,
respiratory
muscle
strength
,
arterial
blood
gas
tensions
and
ventilation
during
sleep
were
assessed
.
Sixteen
patients
were
studied
(
10
males
;
age
68
.
1
±
9
.
9
years
;
disease
duration
11
.
9
±
5
.
0
years
;
body
mass
index
28
.
5
±
4
.
0
kg
/
m
(
2
)
)
.
Four
reported
excessive
daytime
sleepiness
;
8
had
at
least
mild
dysphagia
;
forced
vital
capacity
was
<
80
%
predicted
normal
in
7
;
sniff
nasal
inspiratory
pressure
was
reduced
in
3
;
daytime
hypoxemia
was
present
in
9
and
hypercapnia
in
one
.
Sleep
study
was
performed
in
15
and
revealed
sleep
disordered
breathing
(
apnoea
-hypopnoea
index
23
.
4
±
12
.
8
(
range
7
-
50
.
3
)
events
/
h
)
in
all
.
There
were
no
consistent
relationships
between
respiratory
function
impairment
,
occurrence
of
sleep
disordered
breathing
,
and
severity
of
peripheral
muscle
weakness
.
Thus
,
asymptomatic
impairment
of
respiratory
function
was
common
and
sleep
disordered
breathing
observed
in
all
patients
tested
,
irrespective
of
daytime
respiratory
function
.
This
suggests
respiratory
function
testing
,
including
sleep
study
,
should
be
performed
routinely
in
IBM
,
irrespective
of
peripheral
muscle
function
or
other
disease
severity
parameters
.
Diseases
Validation
Diseases presenting
"other disease severity parameters"
symptom
inclusion body myositis
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