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Ongoing developments in sporadic inclusion body myositis.
[inclusion body myositis]
Sporadic
inclusion
body
myositis
(
IBM
)
is
an
acquired
muscle
disorder
associated
with
ageing
,
for
which
there
is
no
effective
treatment
.
Ongoing
developments
include
:
genetic
studies
that
may
provide
insights
regarding
the
pathogenesis
of
IBM
,
improved
histopathological
markers
,
the
description
of
a
new
IBM
autoantibody
,
scrutiny
of
the
diagnostic
utility
of
clinical
features
and
biomarkers
,
the
refinement
of
diagnostic
criteria
,
the
emerging
use
of
MRI
as
a
diagnostic
and
monitoring
tool
,
and
new
pathogenic
insights
that
have
led
to
novel
therapeutic
approaches
being
trialled
for
IBM
,
including
treatments
with
the
objective
of
restoring
protein
homeostasis
and
myostatin
blockers
.
The
effect
of
exercise
in
IBM
continues
to
be
investigated
.
However
,
despite
these
ongoing
developments
,
the
aetiopathogenesis
of
IBM
remains
uncertain
.
A
translational
and
multidisciplinary
collaborative
approach
is
critical
to
improve
the
diagnosis
,
treatment
,
and
care
of
patients
with
IBM
.
Diseases
Validation
Diseases presenting
"for which there is no effective treatment"
symptom
inclusion body myositis
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