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Identification of selective immunoglobulin a deficiency by renal biopsy.
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We
report
three
cases
of
selective
immunoglobulin
A
(
IgA
)
deficiency
in
which
lack
of
direct
immunofluorescent
staining
for
IgA
on
renal
biopsy
specimens
contributed
to
the
diagnosis
.
In
two
patients
,
one
with
systemic
lupus
erythematosus
and
the
other
having
asthma
with
nephrotic
syndrome
,
the
diagnosis
of
IgA
deficiency
was
suggested
by
the
complete
absence
of
IgA
on
the
renal
biopsy
.
In
the
third
patient
,
a
renal
transplant
recipient
,
initial
biopsies
demonstrated
donor-derived
IgA
,
which
disappeared
on
subsequent
biopsies
.
The
diagnosis
of
IgA
deficiency
was
confirmed
in
all
three
patients
by
serologic
quantification
of
IgA
.
