Localized lipoatrophia with persistent circulating autoantibodies and partial immunoglobulin A deficiency in a child.

[]

A 7 -year -old Caucasian girl developed lipoatrophic areas on the abdomen and left thigh . Laboratory tests showed a partial IgA deficiency , circulating autoantibodies (ANAs , double - and single -stranded anti-DNAs , rheumatoid factor ). The clinical aspect resembles lipodystrophia centrifugalis abdominalis infantilis , but autoimmune abnormalities suggest connective tissue panniculitis which underlines the overlap between the different forms of localized lipoatrophias .