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[Clinical relevance of immunoglobulin A deficiency in celiac disease].
[]
To
determine
the
prevalence
of
the
IgA
deficiency
in
patients
with
celiac
disease
and
its
influence
on
the
presentation
and
evolution
of
celiac
disease
.
47
patients
with
clinical
and
histological
diagnosis
of
celiac
disease
were
included
.
Seric
immunoglobulin
levels
were
determined
in
all
patients
.
Five
patients
presented
a
low
level
of
IgA
(
IgA-
deficient
group
)
and
42
patients
presented
normal
levels
(
non-
IgA-
deficient
group
)
.
The
age
and
the
relation
male
/
female
were
similar
between
both
groups
.
Presentation
,
clinical
manifestations
,
analytic
data
of
intestinal
malabsorption
,
and
the
radiologic
pattern
were
also
similar
between
both
groups
of
patients
.
There
were
bronchiectasies
in
two
out
of
5
IgA-
deficient
patients
and
in
only
one
out
of
42
non-
IgA-
deficient
patients
(
p
<
0
.
05
)
.
None
of
the
IgA-
deficient
group
showed
complications
due
to
the
celiac
disease
,
meanwhile
3
non-
IgA
deficient
patients
developed
intestinal
lymphoma
(
p
=
NS
)
.
The
IgA
deficiency
is
frequently
associated
to
celiac
disease
.
This
association
does
not
seem
to
influence
in
a
significant
way
the
presentation
or
the
evolution
of
celiac
disease
.
