Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases.
[]
Evidence
of
immune
system
aberrations
in
patients
with
epilepsy
includes
antiphospholipid
antibody
positivity
in
adult
patients
with
epilepsy
with
a
prevalence
of
19
-
26
%
and
in
13
%
of
children
with
partial
epilepsy
.
Also
immunoglobulin
A
deficiency
has
been
reported
to
exist
in
up
to
25
%
of
epilepsy
patients
.
The
possible
role
of
immune
mechanisms
in
the
pathogenesis
of
childhood
epilepsy
is
clinically
supported
by
the
effectiveness
of
immunomodulatory
treatments
in
cases
with
catastrophic
childhood
epilepsies
.
We
analyzed
a
set
of
various
autoantibodies
in
50
consecutive
children
with
epilepsy
and
in
20
healthy
control
subjects
.
None
of
the
children
had
any
clinical
signs
of
immune
system
disorders
.
The
main
result
was
a
significantly
(
P
=
0
.
011
)
higher
prevalence
of
antiphospholipid
antibodies
in
the
study
group
(
44
%
)
compared
with
controls
(
10
%
)
.
These
antibodies
were
unexpectedly
common
(
71
-
80
%
)
in
children
with
multiple
seizure
types
associated
often
with
symptomatic
etiology
,
early
onset
and
high
frequency
of
seizures
.
There
was
no
evidence
of
the
antiphospholipid
positivity
being
induced
by
certain
AEDs
(
e
.
g
.
phenytoin
or
carbamazepine
)
.
Even
though
the
significance
of
these
autoantibodies
remains
unknown
,
their
increased
prevalence
indicates
that
immune
system
mediated
mechanisms
may
have
a
role
in
the
manifestation
of
epilepsy
in
some
children
.
