Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Frequent false positive beta human chorionic gonadotropin tests in immunoglobulin A deficiency.
[]
A
patient
with
IgA
deficiency
had
a
series
of
positive
serum
pregnancy
tests
which
led
to
medical
and
surgical
procedures
for
suspected
molar
pregnancy
.
These
tests
were
found
to
be
falsely
positive
due
to
heterophile
antibody
.
The
aim
of
this
study
was
to
determine
the
frequency
of
false
positive
betahCG
assays
in
sera
of
IgA
deficient
patients
.
Sera
from
a
panel
of
IgA
deficient
(
IgA
<
7
mg
/
dl
)
patients
were
tested
for
the
presence
of
betaHCG
using
three
different
assays
,
and
also
for
IgG
anti-goat
and
anti-mouse
antibodies
.
Patients
were
seen
at
Mount
Sinai
Medical
Center
and
included
54
patients
(
ages
1
-
80
years
,
32
females
,
22
males
)
with
IgA
deficiency
.
Thirty
percent
of
54
IgA
deficient
patient
sera
yielded
positive
pregnancy
tests
by
one
or
more
of
the
three
betahCG
assays
,
however
,
none
of
the
patients
were
pregnant
.
In
comparison
to
sera
of
normal
controls
,
39
%
of
the
patient
sera
contained
significant
amounts
of
anti-goat
antibody
and
18
%
contained
significant
amounts
of
anti-mouse
antibody
.
While
heterophile
antibodies
are
common
in
IgA
deficient
serum
,
false
positive
assays
for
betahCG
in
IgA
deficient
serum
have
not
been
previously
reported
.
The
possibility
of
false
positive
test
results
should
be
considered
prior
to
invasive
procedures
in
IgA
deficient
patients
.
