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Association of HLA-*08:DRB1*03 with immunoglobulin A-deficiency.
[]
Susceptibility
to
IgA
deficiency
(
IgAD
)
is
strongly
associated
with
alleles
of
HLA
,
but
it
is
not
equally
strong
in
different
human
populations
.
Therefore
,
the
goal
of
this
study
was
to
determine
the
HLA-A
,
-
B
and
-
DRB
1
antigenic
and
haplotypic
frequencies
in
unrelated
Polish
Caucasian
IgA-
deficient
patients
who
had
never
been
examined
so
far
in
this
respect
.
The
HLA
alleles
were
determined
by
means
of
low
resolution
polymerase
chain
reaction
with
sequence
specific
primers
(
PCR-SSP
)
method
in
a
group
of
IgA-
deficient
patients
and
control
subjects
from
the
same
area
.
The
HLA-DRB
1
*
03
allele
showed
the
strongest
association
with
IgA
deficiency
in
the
Polish
population
(
OR
=
6
.
6
,
p
cor
=
0
.
0084
)
.
The
HLA-B
*
08
allele
was
also
associated
with
predisposition
to
the
disease
(
OR
=
6
.
22
,
p
cor
=
0
.
033
)
.
These
significant
associations
could
be
explained
in
the
context
of
a
positive
association
of
IgAD
with
the
HLA-B
*
08
:
DRB
1
*
03
haplotype
,
previously
reported
in
other
Caucasoid
populations
from
Northern
and
Central
Europe
.
In
our
group
the
HLA-B
*
08
:
DRB
1
*
03
haplotype
was
present
in
52
.
9
%
of
IgA-
deficient
patients
comparing
to
9
.
9
%
in
controls
(
p
<
0
.
00011
)
.
A
positive
association
of
HLA-B
*
08
and
DRB
1
*
03
was
stronger
in
IgA-
deficient
males
than
in
females
from
the
same
group
.
Immunoglobulin
A
deficiency
in
Polish
population
is
strongly
associated
with
HLA-B
*
08
:
DRB
1
*
03
haplotype
rather
than
with
single
alleles
.
