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Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findings.
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Selective
deficiency
of
immunoglobulin
A
(
IgA
)
is
the
most
frequent
primary
hypogammaglobulinemia
.
As
some
IgA-
deficient
patients
have
IgA
antibodies
in
their
plasma
which
may
cause
anaphylactic
reactions
,
blood
centers
usually
maintain
a
list
of
IgA-
deficient
blood
donors
to
prepare
compatible
blood
components
.
In
this
study
we
determined
the
incidence
of
selective
IgA
deficiency
(
SIgAD
)
in
normal
adult
Iranian
population
.
13022
normal
Iranian
blood
donors
were
included
in
this
study
.
The
assay
which
we
used
was
adapted
to
the
manual
pipetting
system
and
ELISA
reader
was
used
for
screening
.
Other
classes
of
immunoglobulins
(
G
,
M
)
,
as
well
as
secretory
IgA
and
IgG
subclasses
were
tested
in
IgA
deficient
cases
by
ELISA
.
SPSS
was
used
for
statistical
analysis
.
Among
13022
studied
cases
,
11608
blood
donors
were
males
(
89
.
14
%
)
and
1414
were
females
(
10
.
86
%
)
.
Their
mean
(
+
/
-
SD
)
age
and
weight
were
38
.
5
+
/
-
11
years
and
82
+
/
-
12
Kg
respectively
.
Twenty
of
the
screened
samples
were
found
by
means
of
ELISA
to
be
IgA-
deficient
(
less
than
5
mg
/
dl
)
,
(
frequency
;
1
:
651
)
.
The
data
could
indicate
a
compensation
for
IgA
deficiency
by
serum
IgM
in
one
of
our
IgA
deficient
cases
(
Patient
5
)
.
We
observed
a
correlation
between
IgG
3
and
serum
IgA
in
deficient
cases
(
r
=
0
.
498
,
P
=
0
.
025
)
.
Our
results
indicate
that
in
present
study
the
prevalence
of
S
IgA
D
is
in
agreement
with
data
from
other
Caucasians
populations
(
from
1
:
300
to
1
:
700
)
.
In
conclusion
,
Selective
IgA
Deficiency
could
be
almost
asymptomatic
in
most
cases
in
general
population
.
Our
study
suggests
that
;
due
to
high
frequency
of
IgA
deficiency
in
Iran
,
it
seems
necessary
to
measure
IgA
levels
for
every
blood
donor
and
blood
recipient
to
find
IgA
deficient
cases
.
