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Prevalence of autism spectrum disorders in relatives of patients with selective immunoglobulin A deficiency.
[]
An
association
of
selective
IgA
(
immunoglobulin
A
)
deficiency
in
individuals
with
autism
has
been
previously
described
.
The
objective
of
this
study
was
to
examine
the
incidence
of
autism
spectrum
disorders
(
ASD
)
in
children
and
siblings
of
selective
IgA
deficient
patients
.
to
assess
the
likelihood
of
parents
with
the
most
common
type
of
primary
immunodeficiency
(
selective
IgA
deficiency
)
having
children
with
ASD
and
to
investigate
the
occurrence
of
ASD
in
siblings
of
the
immunodeficient
patients
.
A
study
was
conducted
in
31
selective
IgA
deficient
patients
and
62
age
and
gender-matched
controls
.
Children
and
siblings
of
IgA
deficient
patients
and
controls
were
screened
for
an
ASD
(
autism
spectrum
disorder
)
using
a
standard
questionnaire
.
Only
one
patient
in
the
IgA
deficient
group
had
classical
autism
.
Three
children
in
that
group
(
10
.
3
%
)
had
an
ASD
compared
to
only
one
in
the
control
group
(
1
.
6
%
)
and
this
difference
was
statistically
significant
.
In
terms
of
siblings
,
there
was
a
higher
occurrence
of
an
ASD
in
the
IgA
deficient
group
than
in
the
control
group
,
but
the
difference
was
not
statistically
significant
.
A
high
incidence
of
allergies
(
71
%
)
was
documented
in
IgA
deficient
patients
.
All
individuals
with
allergies
had
food
sensitivities
.
There
was
a
predominance
of
the
male
gender
in
cases
identified
with
an
ASD
in
all
groups
.
A
lower
prevalence
of
ASD
was
observed
in
the
IgA
deficient
group
,
as
compared
to
other
reports
.
The
study
suggests
that
screening
for
an
ASD
seems
appropriate
for
children
of
IgA
deficient
patients
.
