[Selective immunoglobulin A deficiency].

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Immunoglobulin class A is the main protein of the mucosal immune system . Selective immunoglobulin A deficiency (sIgAD ) is the most common primary immunodeficiency in Caucasians . sIGAD is strongly associated with the certain major histocompatibility complex region . Most individuals with sIgAD are asymptomatic and identified coincidentally . However , some patients may present with recurrent infections , allergic disorders and autoimmune manifestations . Several autoimmune diseases , such as systemic lupus erythematosus , diabetes mellitus type 1 , Graves disease and celiac disease , are associated with an increased prevalence of sIgAD . Screening for sIgAD in coeliac disease is essential . Patients need treatment of associated diseases . It is also known that IgA deficiency may progress into a common variable immunodeficiency (CVID ). Pathogenesis and molecular mechanism involved in sIgAD should be elucidated in the future .