An uncommon association of antiphospholipid syndrome, selective IgA deficiency and resistant-to-treatment relapsing polychondritis: efficacy of infliximab.

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Autoimmune complications in the context of primary immunodeficiency diseases represent a well-known phenomenon , and this is widely recognized also for Selective Immunoglobulin A deficiency (IgAD ), the most common primary antibody deficiency (PAD ). Relapsing polychondritis (RP ) is a rare immune-mediated , difficult to treat , disorder in which the cartilaginous tissues are the target for inflammation and damage . Ocular inflammatory manifestations in RP are frequent and often sight-threatening . Antiphospholipid syndrome (APS ) is an acquired prothrombotic state related to circulating autoantibodies against phospholipids and /or their cofactors . Rare reports of APS associated to RP , PAD and APS or PAD and RP are available .