[Importance of selective immunoglobulin A deficiency].

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Selective IgA deficiency is the most common primary immunodeficiency . Little is known about the pathogenetic mechanisms leading to this disease . It is estimated that the incidence of this disease in Spain is 1 :163 . We report 3 cases diagnosed in Primary Care . Most people with selective IgA deficiency are usually asymptomatic and are diagnosed by chance , but patients with recurrent respiratory infections ; gastrointestinal , allergic and autoimmune diseases can be associated with this disease . Although there is no treatment at present , its importance lies in the association with different diseases , such as coeliac disease or idiopathic thrombocytopenic purpura . Another important feature is the risk of anaphylaxis after transfusion , and the possible progression to Common Variable Immunodeficiency . It is important to know the vaccines that we can use due to the risk of disease .