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[Parodontitis pathogenetic factors, their interaction and effects].
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Induced
by
microbial
intervention
oxidative
stress
causes
electronic
transport
disorder
in
gingival
cells
mitochondrias
as
well
as
decrease
of
energogenesis
and
increase
of
lipoperoxidation
.
In
oral
cavity
local
immunity
is
decreased
in
parodontitis
,
that
is
related
with
immunoglobulin
A
deficiency
and
lysozyme
activity
decrease
.
Against
this
background
,
microbial
factors
damaging
effect
on
periodont
is
intensified
.
In
parodontitis
the
free
nitric
oxide
(
NO
)
content
decrease
in
gingival
tissues
and
its
appearance
in
saliva
is
related
with
transformation
of
NO
into
toxic
peroxinitrite
,
that
on
its
turn
enhances
oxidation
,
parodontal
injury
,
cell
degra
dation
and
necrosis
.
Nitrooxide
defficiency
in
gingival
mucosal
cells
is
characterized
by
decreased
protein
P-
53
expression
and
terminal
differentiation
disorder
of
the
cells
.
Mitochodria
related
energogenesis
disorder
in
gums
causes
inhibition
of
their
cell
regeneration
,
which
together
with
apoptotic
changes
is
characterized
with
parodontal
tissue
destruction
and
depletion
.
