Craniofacial and dental manifestations of triple X syndrome associated with congenital hypothyroidism: a case report.

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Triple X syndrome (47 ,XXX ) is a numerical chromosomal alteration that affects 1 /1 ,000 women , in which the woman is born with an extra X chromosome . Some oral changes have been reported in the literature , as hypodontia , influence on deposition of crown enamel and discrepancies in cephalometric measurements . Other systemic complications may lead to oral abnormalities similar to those seen in triple X patients , such as congenital hypothyroidism (CH ). This paper reports a triple X syndrome case associated with CH later treated . Besides delay in cognitive and intellectual development , the patient had changes in teeth development and in cephalometric measurements with deficiencies in the maxilla and mandible . This is the first report of a triple X syndrome associated with CH . Both conditions may result in changes in dentofacial development .