Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!

[]

Non-syndromic tooth agenesis is a congenital anomaly with significant medical , psychological , and social ramifications . There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes .The aim of this study was to test whether MSX 1 671 T > C gene variant was involved in etiology of non-syndromic tooth agenesis in Raichur patients .Blood samples were collected with informed consent from 50 subjects having non-syndromic tooth agenesis and 50 controls . Genomic deoxyribonucleic acid (DNA ) was extracted from the blood samples , polymerase chain reaction (PCR ) was performed , and restriction fragment length polymorphism (RFLP ) was performed for digestion products that were evaluated .The results showed positive correlation between MSX 1 671 T > C gene variant and non-syndromic tooth agenesis in Raichur patients .MSX 1 671 T > C gene variant may be a good screening marker for non-syndromic tooth agenesis in Raichur patients .