Colorectal cancer and self-reported tooth agenesis.

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Germline mutations in APC and AXIN 2 are both associated with colon neoplasia as well as anomalous dental development . We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis .Via a survey conducted on 1636 individuals with colorectal cancer (CRC ) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry , self-reported information on congenitally missing teeth was collected . The frequency of missing teeth between cases and controls was compared using Pearson 's chi -squared test or Fisher 's exact test .4 .8 % of cases and 5 .7 % of controls reported having at least one missing tooth (p â€‰=â€‰0 .20 ). When we stratified by recruitment site , gender , and mutation status where available , frequency of missing teeth was not statistically significantly different between cases and controls .This study did not provide support for there being a general predisposition to missing teeth among a large cohort of CRC patients . The study neither addresses nor excludes the possibility , however , that individuals presenting with notable hypodontia /oligodontia might still have an increased risk for colorectal neoplasia .