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Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population.
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Tooth
agenesis
is
one
of
the
most
common
anomalies
of
human
dentition
.
Recent
genetic
studies
have
provided
information
regarding
a
number
of
genes
related
to
both
syndromic
and
non-syndromic
forms
of
hypodontia
.
In
a
previous
study
,
we
found
that
polymorphism
in
rs
11001553
of
DKK
1
was
associated
with
hypodontia
in
the
Chinese
Han
population
.
In
this
study
,
we
extended
this
investigation
to
89
individuals
diagnosed
with
sporadic
non-syndromic
oligodontia
(
40
males
and
49
females
)
.
These
individuals
were
analyzed
with
268
subjects
(
123
males
and
145
females
)
diagnosed
with
non-syndromic
hypodontia
and
190
healthy
control
subjects
(
99
males
and
91
females
)
.
DNA
was
obtained
from
whole
blood
or
saliva
samples
and
genotyping
was
performed
by
matrix-assisted
laser
desorption
ionization-time
of
flight
mass
spectrometry
.
Significant
differences
were
observed
in
the
allele
and
genotype
frequencies
of
rs
11001553
of
DKK
1
.
These
data
demonstrated
an
association
between
rs
11001553
of
DKK
1
,
a
tooth
development-associated
gene
,
and
non-syndromic
tooth
agenesis
in
Chinese
Han
individuals
.
This
information
may
provide
further
understanding
of
the
molecular
mechanisms
of
tooth
agenesis
.
Furthermore
,
DKK
1
can
be
regarded
as
a
marker
gene
for
the
risk
of
tooth
agenesis
.
