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Assessment of cerebrospinal fluid flow patterns using the time-spatial labeling inversion pulse technique with 3T MRI: early clinical experiences.
[hydrocephalus with stenosis of the aqueduct of sylvius]
CSF
imaging
using
the
time-spatial
labeling
inversion
pulse
(
time-
SLIP
)
technique
at
3
T
magnetic
resonance
imaging
(
MRI
)
was
performed
to
assess
cerebrospinal
fluid
(
CSF
)
dynamics
.
The
study
population
comprised
15
healthy
volunteers
and
five
patients
with
MR
findings
showing
expansive
dilation
of
the
third
and
lateral
ventricles
suggesting
aqueductal
stenosis
(
AS
)
.
Signal
intensity
changes
were
evaluated
in
the
tag-labeled
CSF
,
untagged
brain
parenchyma
,
and
untagged
CSF
of
healthy
volunteers
by
changing
of
black-
blood
time-inversion
pulse
(
BBTI
)
.
CSF
flow
from
the
aqueduct
to
the
third
ventricle
,
the
aqueduct
to
the
fourth
ventricle
,
and
the
foramen
of
Monro
to
the
lateral
ventricle
was
clearly
rendered
in
all
healthy
volunteers
with
suitable
BBTI
.
The
travel
distance
of
CSF
flow
as
demonstrated
by
the
time-
SLIP
technique
was
compared
with
the
distance
between
the
aqueduct
and
the
fourth
ventricle
.
The
distance
between
the
foramen
of
Monro
and
the
lateral
ventricle
was
used
to
calculate
the
CSF
flow
/
distance
ratio
(
CD
ratio
)
.
The
CD
ratio
at
each
level
was
significantly
reduced
in
patients
suspected
to
have
AS
compared
to
healthy
volunteers
.
CSF
flow
was
not
identified
at
the
aqueductal
level
in
most
of
the
patients
.
Two
patients
underwent
time-
SLIP
assessments
before
and
after
endoscopic
third
ventriculostomies
(
ETVs
)
.
CSF
flow
at
the
ETV
site
was
confirmed
in
each
patient
.
With
the
time-
SLIP
technique
,
CSF
imaging
is
sensitive
enough
to
detect
kinetic
changes
in
CSF
flow
due
to
AS
and
ETV
.