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Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory.
[22q11.2 deletion syndrome]
Individuals
with
chromosome
22
q
11
.
2
deletion
syndrome
(
22
q
11
.
2
DS
)
have
been
shown
to
have
impairments
in
processing
spatiotemporal
information
.
The
authors
examined
whether
children
with
22
q
11
.
2
DS
exhibit
impairments
in
spatial
working
memory
performance
due
to
these
weaknesses
,
even
when
controlling
for
maintenance
of
attention
.
Children
with
22
q
11
.
2
DS
(
n
 
=
 
47
)
and
typically
developing
controls
(
n
 
=
 
49
)
ages
6
-
15
years
saw
images
within
a
grid
and
after
a
delay
,
then
indicated
the
positions
of
the
images
in
the
correct
temporal
order
.
Children
with
22
q
11
.
2
DS
made
more
spatial
and
temporal
errors
than
controls
.
Females
with
22
q
11
.
2
DS
made
more
spatial
and
temporal
errors
than
males
.
These
results
extend
findings
of
impaired
spatiotemporal
processing
into
the
memory
domain
in
22
q
11
.
2
DS
by
documenting
their
influence
on
working
memory
performance
.
Diseases
Validation
Diseases presenting
"impaired spatiotemporal processing into the memory domain"
symptom
22q11.2 deletion syndrome
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