Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory.

[22q11.2 deletion syndrome]

Individuals with chromosome 22 q 11 .2 deletion syndrome (22 q 11 .2 DS ) have been shown to have impairments in processing spatiotemporal information . The authors examined whether children with 22 q 11 .2 DS exhibit impairments in spatial working memory performance due to these weaknesses , even when controlling for maintenance of attention . Children with 22 q 11 .2 DS (n = 47 ) and typically developing controls (n = 49 ) ages 6 -15 years saw images within a grid and after a delay , then indicated the positions of the images in the correct temporal order . Children with 22 q 11 .2 DS made more spatial and temporal errors than controls . Females with 22 q 11 .2 DS made more spatial and temporal errors than males . These results extend findings of impaired spatiotemporal processing into the memory domain in 22 q 11 .2 DS by documenting their influence on working memory performance .