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Cyclic mood disorder heralding adult-onset autosomal dominant leucodystrophy: a clinical masquerader.
[alexander disease]
Leucodystrophies
are
a
heterogeneous
group
of
progressive
white
matter
diseases
which
may
be
inherited
in
dominant
,
recessive
or
X-
linked
fashion
depending
on
the
type
.
Adrenoleucodystrophy
(
ALD
)
and
metachromatic
leucodystrophy
(
MLD
)
are
rather
commoner
forms
of
leucodystrophies
whereas
krabbes
disease
,
alexander
disease
,
cannavans
disease
etc
.
are
of
less
common
type
.
Adult-onset
autosomal
dominant
leucodystrophy
(
ADLD
)
is
a
lately
described
rarer
form
of
leucodystrophy
with
perhaps
no
case
report
from
India
.
Various
leucodystrophies
may
have
different
clinical
presentations
,
ranging
from
subtle
cognitive
and
psychiatric
manifestations
to
gross
motor
disabilities
,
visual
impairment
and
seizure
.
Psychiatric
manifestations
in
the
form
of
psychoses
and
frank
schizophrenia
are
commonly
described
in
MLD
.
Depression
though
uncommonly
reported
in
MLD
,
cyclic
mood
disorders
have
been
rarely
described
in
any
form
of
leucodystrophies
.
We
are
reporting
an
eye
opener
,
a
case
of
ADLD
which
masqueraded
as
a
rapid
cyclic
mood
disorder
for
initial
four
years
,
later
to
be
followed
by
progressive
neurological
signs
and
symptoms
.
To
the
best
of
our
knowledge
,
this
is
perhaps
the
first
case
report
of
ADLD
presenting
as
rapid
cyclic
mood
disorder
in
the
world
literature
.
Diseases
Validation
Diseases presenting
"common type"
symptom
alexander disease
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
erythropoietic protoporphyria
esophageal carcinoma
hereditary cerebral hemorrhage with amyloidosis
liposarcoma
oculocutaneous albinism
oligodontia
pendred syndrome
pleomorphic liposarcoma
pyomyositis
well-differentiated liposarcoma
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