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Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging).
[adrenomyeloneuropathy]
The
magnetization
transfer
ratio
(
MTR
)
is
a
reliable
measure
of
MT
effects
because
it
employs
an
internal
standard
that
allows
quantitative
comparison
between
subjects
,
independent
of
other
contrasts
,
coil
loading
,
and
coil
sensitivity
profiles
.
However
,
at
very
high
spatial
resolution
in
the
spinal
cord
at
1
.
5
T
,
the
use
of
MTR
quantification
has
been
hampered
by
low
signal-
to
-noise
ratio
(
SNR
)
and
acute
sensitivity
to
motion
.
Here
,
the
suitability
of
cerebrospinal
fluid
(
CSF
)
as
an
alternative
inter-subject
MT
signal
intensity
reference
for
the
spine
is
evaluated
.
Contrary
to
MTR
,
this
so
-called
MTCSF
internal
standard
does
not
remove
interfering
T
(
1
)
,
T
(
2
)
,
and
spin
density
contrast
and
is
not
expected
to
be
able
to
discriminate
between
myelination
and
inflammation
effects
.
However
,
it
can
detect
initial
changes
in
myelination
when
signal
alterations
are
not
yet
detectable
by
conventional
MRI
.
As
a
first
example
,
this
is
demonstrated
for
the
noninflammatory
spinal
cord
white
matter
disease
adrenomyeloneuropathy
.
Diseases
Validation
Diseases presenting
"this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy"
symptom
adrenomyeloneuropathy
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