Anesthesia for cesarean section in a patient with Holt-Oram syndrome.

[holt-oram syndrome]

Holt-Oram syndrome is a rare genetic disorder affecting the heart and upper limbs (atriodigital dysplasia ). The manifestations of the limb defects may vary in severity from subtle carpal bone defects and triphalangeal thumb to digit aplasia and upper extremity phocomelia . Cardiac abnormalities include atrial and /or ventricular septal defects , anomalies in pulmonary venous return and various dysrhythmias . We present the anesthetic management of a parturient with this syndrome who underwent elective cesarean section and tubal ligation , conducted under combined spinal -epidural anesthesia with a low dose of intrathecal bupivacaine . Our goal was to avoid an excessively high sympathetic block or excessive sympathetic stimulation accompanied by potential deleterious effects on cardiac rhythm . Cardiac monitoring was continued in the postoperative period for 6 h because of the possibility of dysrhythmia .

Diseases
Validation

Diseases presenting "cardiac abnormalities" symptom

22q11.2 deletion syndrome

holt-oram syndrome

hydrocephalus with stenosis of the aqueduct of sylvius

inclusion body myositis

kabuki syndrome

monosomy 21

pyruvate dehydrogenase deficiency

wiskott-aldrich syndrome

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