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Prostate Cancer in a Male with Holt-Oram Syndrome: First Clinical Association of the TBX5 Mutation.
[holt-oram syndrome]
Holt-
Oram
syndrome
is
an
autosomal
dominant
disorder
which
is
caused
by
mutations
of
TBX
5
and
is
characterised
by
cardiac
and
skeletal
abnormalities
.
TBX
5
is
part
of
the
T
-
box
gene
family
and
is
thought
to
upregulate
tumour
cell
proliferation
and
metastasis
when
mutated
.
We
report
the
first
clinical
case
of
prostate
cancer
in
an
individual
with
Holt
Oram
syndrome
.