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Diversity of congenital cardiac defects and skeletal deformities associated with the Holt-Oram syndrome.
[holt-oram syndrome]
The
Holt-
Oram
syndrome
is
a
rare
congenital
disorder
involving
the
skeletal
and
cardiovascular
systems
.
It
is
characterized
by
upper
limb
deformities
and
cardiac
malformations
,
atrial
septal
defects
in
particular
.
Four
consecutive
patients
1
-
15
years
old
with
the
Holt-
Oram
syndrome
presented
over
a
10
year
span
for
surgical
treatment
of
their
cardiac
maladies
.
The
spectrum
of
the
heart
defects
and
skeletal
deformities
encountered
in
these
patients
are
described
and
discussed
.
The
Holt-
Oram
syndrome
is
an
autosomal
dominant
condition
;
however
absence
of
the
morphological
features
of
the
trait
in
close
family
members
is
not
rare
.
Although
patients
are
known
to
predominately
present
with
atrial
septal
defects
,
other
cardiovascular
anomalies
,
including
rhythm
abnormalities
,
are
not
uncommon
.
Skeletal
disorders
vary
as
well
.
Cardiovascular
disorders
,
skeletal
malformations
and
familial
expression
of
the
Holt-
Oram
syndrome
,
vary
widely
.