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Hodgkin lymphoma: pathology, pathogenesis, and a plethora of potential prognostic predictors.
[hodgkin lymphoma, classical]
Hodgkin
lymphoma
(
HL
)
encompasses
2
unique
clinicopathologic
entities
,
classical
Hodgkin
lymphoma
(
CHL
)
(
∼
95
%
of
cases
)
and
nodular
lymphocyte
predominant
HL
(
∼
5
%
of
cases
)
.
Both
subtypes
demonstrate
a
paucity
of
surreptitious
(
in
CHL
)
neoplastic
B
cells
within
a
background
of
reactive
inflammatory
cells
underscoring
both
the
relatedness
of
these
2
entities
to
each
other
,
as
well
as
their
distinction
from
other
types
of
lymphoid
neoplasia
.
Clinically
,
they
are
primarily
nodal
diseases
that
disseminate
in
a
predictable
manner
to
contiguous
nodal
regions
.
The
biology
of
HL
as
a
whole
,
as
well
as
the
genetic
and
pathologic
features
that
distinguish
CHL
from
nodular
lymphocyte
predominant
HL
and
other
lymphomas
has
been
the
subject
of
a
wealth
of
investigation
in
recent
decades
.
The
aim
of
this
review
is
to
detail
the
pathologic
features
of
HL
and
to
highlight
the
recent
insights
into
its
molecular
basis
and
the
myriad
prognostic
markers
being
described
.
Diseases
Validation
Diseases presenting
"neoplasia"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
aniridia
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
pyomyositis
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated
